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Direct acting agents (agonists) activate the receptor site by mimicking the effects of acetylcholine.

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ChEIs prevent the degradation of acetylcholine (ACh) by inhibiting the enzyme acetylcholinesterase (AChE), resulting in increased levels of ACh in the synaptic cleft available for receptor absorption.

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Figure 6 is a histogram of the percentage distribution of CIBIC-plus scores attained by patients assigned to each of the three treatment groups who completed 26 weeks of treatment.

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The brain regions that are active during working memory tasks are also being evaluated, and research has shown that different parts of the brain are activated during working memory in younger adults as compared to older adults.

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Most of the supplements failed to show beneficial effects for CFS, with the exception of NADH and magnesium.

The safety of the extended-release capsule and immediate-release tablet formulations of galantamine was evaluated in 3956 galantamine-treated patients who participated in 8 placebo-controlled clinical studies and 1454 subjects in 5 open-label clinical studies with mild to moderate dementia of the Alzheimer's type.

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