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The authors conclude that PTNS significantly improves OAB symptoms, that the effects are similar in magnitude to anti-muscarinics, but that PTNS has a better adverse event profile.

Ten patients (two on placebo, six on tolterodine and two on oxybutynin) took antimuscarinic drugs or drugs with antimuscarinic adverse effects during the treatment period, most commonly as inhaled ipratropium bromide for the treatment of asthma, but this was not thought to have affected the findings of the study.

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Blood, serum or plasma topiramate concentrations may be measured using immunoassay or chromatographic methods to monitor therapy, confirm a diagnosis of poisoning in hospitalized patients or to assist in a medicolegal death investigation.

Since the elderly have less participation in drug trials, there is insufficient information on the side effects and adverse reactions of drugs on the elderly.

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In the original literature review thirteen studies, predominantly single-group observational designs, evaluated sacral neuromodulation in patients with severe refractory OAB symptoms, many of whom had failed multiple other therapies.

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