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Due to recent well-designed studies, the American Geriatrics Society (AGS) and the British National Institute for Health and Clinical Excellence and Social Care Institute of Excellence (NICE-SCIE) have concluded that non-drug treatments should be tried first, and symptoms should be managed with non-drug strategies in most circumstances.
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To evaluate the efficacy and safety of the β3-adrenoceptor agonist mirabegron, in a Japanese population with overactive bladder (OAB).
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Clinicians should offer oral anti-muscarinics or oral β3-adrenoceptor agonists as second-line therapy.
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The authors conclude that PTNS significantly improves OAB symptoms, that the effects are similar in magnitude to anti-muscarinics, but that PTNS has a better adverse event profile.
Ten patients (two on placebo, six on tolterodine and two on oxybutynin) took antimuscarinic drugs or drugs with antimuscarinic adverse effects during the treatment period, most commonly as inhaled ipratropium bromide for the treatment of asthma, but this was not thought to have affected the findings of the study.
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I-A) To decrease side effects, switching to a lower dose or using an extended release formulation or a transdermal delivery mechanism should be considered.
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Bladder rehabilitation, the effect of a cognitive training programme on urge incontinence.
Blood, serum or plasma topiramate concentrations may be measured using immunoassay or chromatographic methods to monitor therapy, confirm a diagnosis of poisoning in hospitalized patients or to assist in a medicolegal death investigation.
Since the elderly have less participation in drug trials, there is insufficient information on the side effects and adverse reactions of drugs on the elderly.
Our analysis suggests that a change from tolterodine ER-based therapy to fesoterodine in symptomatic OAB patients was associated with increased patient treatment benefit.
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Meilahn (2013) evaluated the tolerability and effectiveness of the WalkAide neuroprosthesis in a small observational study of 10 children (7 to 12 years old) with hemiparetic CP who used an AFO for correction of foot drop.
Intrathecal baclofen can be associated with significant side effects in some cases.
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This formulation yields a flatter serum concentration profile and provides clinically meaningful symptom improvement as early as week 1 of treatment.
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Constipation can cause detrusor instability, and children with detrusor instability who use posturing maneuvers to avoid incontinence are at risk for urinary tract infections.
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Sanctura may also be used for purposes not listed in this medication guide.
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Leong (2011) reported that although 90% of patients reported satisfaction with SNS, 56% reported adverse events, particularly pain at the stimulator site and when the stimulator was turned on and daily life limitations, such as difficulty passing through airport metal detectors and inability to undergo magnetic resonance imaging (MRI).
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In the original literature review thirteen studies, predominantly single-group observational designs, evaluated sacral neuromodulation in patients with severe refractory OAB symptoms, many of whom had failed multiple other therapies.
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The L1CAM gene mutation that causes SPG1 also causes MASA syndrome, X-linked corpus callosum agenesis, and X-linked hydrocephalus with stenosis of the aqueduct of Sylvius.
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What are the treatments for an overactive bladder?
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The BPH Impact Index (BII) (Appendix A5) is a questionnaire that assesses the effect of symptoms on everyday life and their interference with daily activities, thus capturing the impact of the condition.
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Complex forms may occur with additional symptoms including upper limb amyotrophy, intellectual disability, hearing loss and retinitis pigmentosa, a general term for a group of vision disorders that cause progressive degeneration of the membrane lining the eyes (retina) resulting in visual impairment.
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